A1c, complete blood counts should be performed periodically to check for side effects and monitor your response to therapy. Check your blood or urine sugar levels regularly as directed by your doctor or pharmacist. Before taking acarbose, tell your doctor if you have liver disease, or any type of stomach or intestinal disorder. United States and its territories. Indications, uses and warnings on Drugs. cetirizine how long do they last cetirizine
What are the possible side effects of acarbose Precose? This list is not complete and other drugs may affect your blood sugar or interact with acarbose. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. HbA1c levels from baseline throughout a one-year study in patients with type 2 diabetes mellitus when used in combination with: A diet alone; B sulfonylurea; C metformin; or D insulin. buy now cheap budecort store
If you take acarbose with insulin or other diabetes medications, your blood sugar could get too low. Use sugar replacements, such as Splenda, Equal, or Sweet'N Low, instead of sugar. Teratogenic Effects: Pregnancy Category B. The safety of Acarbose Tablets in pregnant women has not been established.
There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification ID bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says that you have diabetes and a list of all of your medicines. Also watch for signs of high blood sugar hyperglycemia such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. AIMS: Thioctic acid TA glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes NIDDM. This study systematically investigated drug-drug interactions between TA and glibenclamide and TA and acarbose. METHODS: Fourteen male and 10 female healthy volunteers participated a randomized, open three period cross over trial treatments A-C followed by a fourth period treatment D. A baseline profile for plasma insulin and glucose concentrations, variables which served as pharmacodynamic measures, was assessed before entering the trial. serophene
If you miss a dose of Glycomet, take as soon as possible. Do not double doses. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Take exactly as prescribed by your Health Provider. In initiating treatment for type 2 diabetes mellitus, diet should be emphasized as the primary form of treatment. Caloric restriction and weight loss are essential in the obese diabetic patient. Proper dietary management alone may be effective in controlling blood glucose and symptoms of hyperglycemia. The importance of regular physical activity when appropriate should also be stressed. Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection. Be sure your family and close friends know how to help you in an emergency. Patients Receiving Sulfonylureas or Insulin: Sulfonylurea agents or insulin may cause hypoglycemia. Acarbose Tablets given in combination with a sulfonylurea or insulin will cause a further lowering of blood glucose and may increase the potential for hypoglycemia. If hypoglycemia occurs, appropriate adjustments in the dosage of these agents should be made. Disclaimer: The indications, uses and warnings for individual medications outside the USA are determined by local regulatory bodies in each country or region. The Drugs.
Bloating; diarrhea; gas; stomach pain. For acarbose to work properly it must be taken at the beginning of each main meal. It may be harder to control your blood sugar during times of stress, such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor. Store acarbose below 77 degrees F 25 degrees C in a tightly sealed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep acarbose out of the reach of children and away from pets. Macrovascular Outcomes: There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with Acarbose Tablets or any other anti-diabetic drug. To evaluate the long-term efficacy of precose in improving glycemic control in subjects with NIDDM, a one-year, multicenter, randomized, double-blind, placebo-controlled study was conducted. The study involved 354 subjects with NIDDM. Clinical studies demonstrated a strong association between hyperglycemia and an increased risk of microvascular tissue damage. Trials involving Precose established that hemoglobin levels are a more significant predictor of the onset or progression of retinopathy in NIDDM diabetic patients than blood glucose concentration. Precose significantly reduced hemoglobin levels in NIDDM subjects maintained on dietary therapy alone. The magnitude of the treatment effect steadily increased during active treatment; diabetic retinopathy was reduced by approximately 30%. Acarbose does not usually cause low blood sugar. Low blood sugar may be more likely to occur if you skip a meal, exercise heavily, or drink alcohol. It may also be more likely if you take acarbose along with certain medicines for diabetes eg, sulfonylureas, insulin. Tell your doctor right away if you experience symptoms of low blood sugar eg, fast heartbeat, headache, chills, sweating, tremors, increased hunger, vision changes, nervousness, weakness, dizziness, drowsiness, fainting. It is a good idea to carry a reliable source of glucose eg, tablets or gel to treat low blood sugar. This will raise your blood sugar level quickly. Because acarbose prevents the breakdown of table cane sugar, be sure to use glucose dextrose not sugar or fruits, to treat symptoms of low blood sugar. Contact your health care provider if you have any questions. Serious and sometimes fatal liver problems have happened with acarbose. Call your doctor right away if you have symptoms of liver problems eg, dark urine, pale stools, persistent loss of appetite, right-sided stomach pain, unusual or severe nausea or tiredness, yellowing of the skin or eyes. Drink plenty of fluids while taking this medication unless your doctor tells you otherwise. It is not known whether acarbose passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using acarbose. TA and S--TA as well as glibenclamide concentrations were measured with specific analytical methods. RESULTS: There was no clinically relevant change of TA enantiomer pharmacokinetics by glibenclamide or acarbose. Also, glibenclamide pharmacokinetics were not altered by TA to a clinically meaningful extent. Plasma insulin and glucose concentrations did not indicate an interaction between TA and glibenclamide or TA and acarbose. Glibenclamide had the expected effect on insulin and glucose levels independent of comedication. There were only minor and short lasting adverse events with the majority being expected hypoglycaemic symptoms occurring during the treatments with glibenclamide. Acarbose slows the digestion of carbohydrates in the body, which helps control blood sugar levels. Higher income. Career mobility. fenofibrate
Low blood sugar hypoglycemia can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of dextrose D-glucose with you in case you have low blood sugar. When taking acarbose, dextrose will work better than cane sugar or table sugar in treating hypoglycemia. Sources of dextrose include honey, dates, raisins, plums, dried prunes, grapes, or glucose tablets. Be sure your family and close friends know how to help you in an emergency. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Take the missed dose as soon as you remember be sure to take it with a meal. If it has been longer than 15 minutes since you started your meal, you may still take acarbose but it may be less effective than taking it with the first bite of the meal. Do not take acarbose between meals, and do not take extra medicine to make up a missed dose. If any of these effects persist or worsen, tell your doctor or promptly. Precose slows the digestion of carbohydrate sugars and starches in the small intestine.
Severe hypoglycemia may require the use of either intravenous glucose infusion or glucagon injection. Symptoms of low blood sugar include anxiety; behavior change similar to being drunk; blurred vision; cold sweats; confusion; cool, pale skin; difficulty in thinking; drowsiness; excessive hunger; fast heartbeat; headache continuing; nausea; nervousness; nightmares; restless sleep; shakiness; slurred speech; or unusual tiredness or weakness. Nursefriendly, Inc. or any of it's affiliated companies. Your medication needs may change if you become sick or injured, if you have a serious infection, or if you have any type of surgery. Do not change your dose or stop taking acarbose without first talking to your doctor. The small intestine stretches. If you miss a dose, take the next dose with your next meal or snack as directed. Initial Dosage: The recommended starting dosage of Acarbose Tablets is 25 mg given orally three times daily at the start with the first bite of each main meal. However, some patients may benefit from more gradual dose titration to minimize gastrointestinal side effects. Hypoglycemia: Because of their mechanism of action, Acarbose Tablets when administered alone should not cause hypoglycemia in the fasted or postprandial state. Sulfonylurea agents or insulin may cause hypoglycemia. Because Acarbose Tablets given in combination with a sulfonylurea or insulin will cause a further lowering of blood glucose, it may increase the potential for hypoglycemia. Hypoglycemia does not occur in patients receiving metformin alone under usual circumstances of use, and no increased incidence of hypoglycemia was observed in patients when Acarbose Tablets were added to metformin therapy. Oral glucose dextrose whose absorption is not inhibited by Acarbose Tablets, should be used instead of sucrose cane sugar in the treatment of mild to moderate hypoglycemia. Sucrose, whose hydrolysis to glucose and fructose is inhibited by Acarbose Tablets, is unsuitable for the rapid correction of hypoglycemia. Other symptoms of low blood sugar such as dizziness, hunger, and sweating are unaffected by these drugs. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. brand nitrofurantoin buy
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Therefore, treatment of these patients with Acarbose Tablets is not recommended. Sorry I couldn't provide a more sound scientific basis, but there are foods around that are not expensive, not genetically engineered, and provided very stable carbohydrate management without having to use a myriad of advanced concoctions. Acarbose has no inhibitory activity against lactase and consequently would not be expected to induce lactose intolerance. The way in which these drugs work is also the major source of their side effects. Although these drugs are very safe, their side effects can be annoying. If digestion is greatly inhibited, this may cause abdominal bloating, gas and diarrhea. The alpha glucosidase inhibitors should always be started on a minimal dose, often half of the smallest tablet, and then gradually increased over time. This greatly minimizes gastric side effects; side effects also tend to decrease over time.
Water pulled out of the bloodstream moves into the small intestine. What is the most important information I should know about acarbose Precose? Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change. Acarbose treatment resulted in a significant increase in the incidence of renal tumors adenomas and adenocarcinomas and benign Leydig cell tumors. This study was repeated with a similar outcome. Further studies were performed to separate direct carcinogenic effects of Acarbose from indirect effects resulting from the carbohydrate malnutrition induced by the large doses of Acarbose employed in the studies. In one study using Sprague-Dawley rats, Acarbose was mixed with feed but carbohydrate deprivation was prevented by the addition of glucose to the diet. In a 26-month study of Sprague-Dawley rats, Acarbose was administered by daily postprandial gavage so as to avoid the pharmacologic effects of the drug. In both of these studies, the increased incidence of renal tumors found in the original studies did not occur. Acarbose was also given in food and by postprandial gavage in two separate studies in Wistar rats. No increased incidence of renal tumors was found in either of these Wistar rat studies. In two feeding studies of hamsters, with and without glucose supplementation, there was also no evidence of carcinogenicity. Do not keep outdated medicine or medicine no longer needed. order spiriva online mastercard canada
Take this medication by mouth, usually 3 times a day at the start with the first bites of each main meal or as directed by your doctor. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. For best results, continue to eat a proper diet, exercise regularly, and check your blood sugar regularly as directed by your doctor. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. The native american diet is largely unchanged, except where Western influence has taken over - hence high rates of obesity, diabetes, and alcoholism - they are all interrelated. Now, understand that I am of Western European descent, so I do NOT consider myself an expert on native american diets. This list is not complete. Other drugs may interact with acarbose, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Store at room temperature below 77 degrees F 25 degrees C away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. People with diabetes must take acarbose with the first bite of food at each meal. Acarbose may be used alone as the only diabetes medicine, or with the group of blood-sugar-lowering medicines called sulfonylureas, such as the brand names Diabeta, Glucotrol, and Micronase. Pediatric Use: Safety and effectiveness of Acarbose Tablets in pediatric patients have not been established. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Some medical conditions may interact with acarbose. Discuss the risks and benefits with your doctor. Acarbose Tablets have been shown to change the bioavailability of digoxin when they are coadministered, which may require digoxin dose adjustment. FDA pregnancy category B. Acarbose is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Do not use table sugar also called cane sugar or sucrose to relieve these symptoms because acarbose delays its breakdown. Carry glucose tablets or gel with you to treat low blood sugar. If you are in a situation where you don't have these reliable forms of glucose, eat some honey or drink a glass of orange juice sources of another sugar, fructose to quickly raise your blood sugar level. Tell your doctor about the reaction right away. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Food and Drug Administration FDA approved the use of acarbose for managing Type 2 diabetes. The brand name for acarbose is Precose. Acarbose blocks the enzymes that digest starches from food. This causes a slower and lower rise of blood sugar through the day. Acarbose is especially effective right after meals. Professor Rury Holman, co-director of the UKPDS, said that patients experienced a very similar reduction in HbA1c over the three-year study period regardless of which existing therapy Precose was added to -- insulin, sulphonylurea, metformin or diet alone. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice. If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting acarbose. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Carefully follow the regular testing of urine or blood glucose schedules given to you by your health care provider. Abteilung Klinische Pharmakologie, Universitat Gottingen, Gottingen, Germany. Acarbose is used along with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Acarbose works by slowing the breakdown of starch carbohydrates from the food you eat into sugar, so that your blood sugar level does not rise as much after a meal. Cut food into very small pieces. Chew well before swallowing. Acarbose Tablets are available as 25 mg, 50 mg and 100 mg for oral use. The inactive ingredients are starch, microcrystalline cellulose, magnesium stearate, and colloidal silicon dioxide. azithromycin
Intestinal adsorbents for example, charcoal and digestive enzyme preparations containing carbohydrate-splitting enzymes for example, amylase, pancreatin may reduce the effect of Acarbose Tablets and should not be taken concomitantly. Nursing Mothers: A small amount of radioactivity has been found in the milk of lactating rats after administration of radiolabeled Acarbose. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, Acarbose Tablets should not be administered to a nursing woman. In a study of 6 healthy men, less than 2% of an oral dose of Acarbose was absorbed as active drug, while approximately 35% of total radioactivity from a 14C-labeled oral dose was absorbed. An average of 51% of an oral dose was excreted in the feces as unabsorbed drug-related radioactivity within 96 hours of ingestion. Because Acarbose acts locally within the gastrointestinal tract, this low systemic bioavailability of parent compound is therapeutically desired. Following oral dosing of healthy volunteers with 14C-labeled Acarbose, peak plasma concentrations of radioactivity were attained 14-24 hours after dosing, while peak plasma concentrations of active drug were attained at approximately 1 hour. The delayed absorption of Acarbose-related radioactivity reflects the absorption of metabolites that may be formed by either intestinal bacteria or intestinal enzymatic hydrolysis. Avoid taking a digestive enzyme such as pancreatin, amylase, or lipase at the same time you take acarbose. These enzymes can make it harder for your body to absorb acarbose. Products that contain digestive enzymes include Arco-Lase, Cotazym, Donnazyme, Pancrease, Creon, and Ku-Zyme. The amount of metformin absorbed while taking Acarbose Tablets was bioequivalent to the amount absorbed when taking placebo, as indicated by the plasma AUC values. However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose Tablets due to a slight delay in the absorption of metformin. There is little if any clinically significant interaction between Acarbose Tablets and metformin. Call your doctor for medical advice about side effects. You may report side effects to Strides Pharma Inc. at 1-877-244-9825 or go to www. When used alone, Precose does not cause low blood glucose hypoglycemia. If used in combination with some diabetes medications hypoglycemia may occur. During treatment initiation and dose titration see below one-hour postprandial plasma glucose may be used to determine the therapeutic response to Acarbose Tablets and identify the minimum effective dose for the patient. Thereafter, glycosylated hemoglobin should be measured at intervals of approximately three months. The therapeutic goal should be to decrease both postprandial plasma glucose and glycosylated hemoglobin levels to normal or near normal by using the lowest effective dose of Acarbose Tablets, either as monotherapy or in combination with sulfonylureas, insulin or metformin. Mostly you will be prescribed one 500mg Glycomet Generic Glucomin tablet 3 times a day, while the 850mg tablets are usually taken twice daily to give effective diabetes control. You should use Glycomet Generic Glucomin only as directed by your doctor. Clinical Experience in Type 2 Diabetes Mellitus Patients on Monotherapy, or in Combination with Sulfonylureas, Metformin or Insulin: Acarbose Tablets were studied as monotherapy and as combination therapy to sulfonylurea, metformin, or insulin treatment. The treatment effects on HbA1c levels and one-hour postprandial glucose levels are summarized for four placebo-controlled, double-blind, randomized studies conducted in the United States in Tables 2 and 3, respectively. The placebo-subtracted treatment differences, which are summarized below, were statistically significant for both variables in all of these studies. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Diabetes patients - Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take acarbose exactly as prescribed, tell your doctor. Glycomet may cause side effects. The information on this page is not a substitute for the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that a drug or drug combination is safe, effective or appropriate for any given patient. Drugs.
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What is acarbose Precose? Use this medication regularly to get the most benefit from it. Take it with every meal or snack. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. money order generic pristiq shop pristiq
Because its mechanism of action is different, the effect of Acarbose Tablets to enhance glycemic control is additive to that of sulfonylureas, insulin or metformin when used in combination. In addition, Acarbose Tablets diminish the insulinotropic and weight-increasing effects of sulfonylureas. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Tell your doctor or dentist that you take acarbose before you receive any medical or dental care, emergency care, or surgery.
Where can I get more information? The fraction of Acarbose that is absorbed as intact drug is almost completely excreted by the kidneys. When Acarbose was given intravenously, 89% of the dose was recovered in the urine as active drug within 48 hours. In contrast, less than 2% of an oral dose was recovered in the urine as active that is, parent compound and active metabolite drug. This is consistent with the low bioavailability of the parent drug. The plasma elimination half-life of Acarbose activity is approximately 2 hours in healthy volunteers. Tell your doctor if you have ever had any unusual or allergic reaction to acarbose or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. vacker.info acticin
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking acarbose while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking acarbose. Using acarbose with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Take the missed dose as soon as you remember be sure to take it with a meal. If it has been longer than 15 minutes since you started your meal, you may still take acarbose but it may be less effective than taking it with the first bite of the meal. Do not take acarbose between meals, and do not take extra medicine to make up a missed dose. What happens if I overdose?